客服电话：全部产品分类
-
购物车共件商品总计：
-
询价列表0共0件商品总计：￥0.00
1. 背景介绍
Titin的主要功能之一是保持肌小节的细胞结构的柔韧性，结构完整性和稳定性。Titin由244个结构域以及之间的肽序列连接组成，这些结构域在蛋白拉伸时去折叠，而在张力去除后重新折叠，通过与其他肌肉蛋白（包括肌动蛋白和肌球蛋白）相互作用，Titin可参与肌肉的收缩和放松过程。 根据现有研究成果，Titin涉及的研究领域较为广泛，除肌肉减少症外还与非酒精性脂肪性肝（NAFLD）、非酒精性脂肪性肝炎（NASH）以及NAFLD的纤维化有关。此外，Titin在运动医学、心脏病、和老年衰弱（frailty）综合征等领域均有研究。 2. 产品应用 独家指标 优势： 可直接检测人尿液中的Titin-N，提供非侵入性研究方式； 抗体特异性强，避免非特异性结合； 使用预包被抗体的96孔板，节约抗体包被时间； 反应时间短：第一次孵育37℃ 1hr，第二次孵育37℃ 0.5hr，显色液孵育37℃ 0.5hr。 Reference 1. Titins:giant proteins in charge of muscle ultrastructure and elasticity. Labeit S, Kolmerer B. Science. October 1995, 270 (5234): 293–6. 2.Unfolding of titin domains explains the viscoelastic behavior of skeletalmyofibrils].Minajeva A, Kulke M, Fernandez JM, LinkeWA. Biophys. J.. March 2001, 80 (3): 1442–51. 3. Usefulness of Urinary N-TerminalFragment of Titin to Predict Mortality in Dilated Cardiomyopathy. Yoshihisa A et al. Am J Cardiol. 2018 Feb 12. pii:S0002-9149(18)30192-9. 4. Matsuo M et al. Titin fragment inurine: A noninvasive biomarker of muscle degradation. Adv Clin Chem. 2019;90: 1-23. 5.Sarcopenia Contributes to the Progression of Nonalcoholic Fatty LiverDisease-Related Fibrosis: A Meta-Analysis. Pan X et al. Dig Dis. 2018Jul 26:1-10. 6.Sarcopenia is an independent risk factor for non-alcoholic steatohepatitis andsignificant fibrosis. Bo Kyung Koo et al. J Hepatol. 2016,66(1):123.7. 7. Diagnostic and clinicalsignificance of the titin fragment in urine of Duchenne muscular dystrophy patients. Awano H et al. Clin Chim Acta. 2018 Jan;476:111-116. 8. Changes in Urinary Titin N-terminalFragment Concentration after Concentric and Eccentric Exercise. Yamaguchi S et al. J Sports Sci Med. 2020 Feb 24;19(1):121-129. 9. Changes in urinary titin N-terminalfragments as a biomarker of exercise-induced muscle damage in the repeated bout effect. Yamaguchi S et al. J Sci Med Sport. 2019 Dec 23.pii: S1440-2440(19)31246-0. 10. UrinaryTitin Is Increased in Patients After Cardiac Surgery. Tanihata J et al. FrontCardiovasc Med. 2019 Feb 8;6:7.
